[Effect of the sympathetic nervous system activation on the antifibrillatory efficacy of various anti-arrhythmia agents] Eksperimental'naia i klinicheskaia farmakologiia. [Eksp Klin Farmakol] Journal article | | Title | [Effect of the sympathetic nervous system activation on the antifibrillatory efficacy of various anti-arrhythmia agents] | | Author(s) | Kaverina NV, Chichkanov GG, Tsorin IB, Kirsanova GIu | | Institution | Laboratory of Circulation System Pharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia. | | Source | Eksp Klin Farmakol 2000 Nov-Dec; 63(6):22-3. | | MeSH | Adrenergic beta-Agonists
Animals
Anti-Arrhythmia Agents
Benzimidazoles
Drug Interactions
English Abstract
Isoproterenol
Male
Moricizine
Rats
Structure-Activity Relationship
Sulfhydryl Compounds
Sympathetic Nervous System
Ventricular Fibrillation
| | Abstract | Experiments with a 7-min occlusion followed by reperfusion of the left coronary artery in narcotized rats showed that antiarrhythmic drugs of various classes--ethacizin (class I), AL-275 (class III), and CM-345 (class V)--produce pronounced antifibrillatory and antiarrhythmic effects. AL-275 and CM-345, in contrast to ethacizin, retained their efficacy under the conditions of isoproterenol-induced stimulation of beta-adrenoceptors. This difference in behavior is probably explained by dissimilar effects of the antiarrhythmics on the ion channels of cardiomyocite membranes. | | Language | rus | | Pub Type(s) | Journal Article
| | PubMed ID | 11202504 |
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